Clinical relevance of biological variation of B-type natriuretic peptide.

with increased concentrations of GAPDH mRNA. Because circulating GAPDH mRNA in cancer patients was thought to originate in apoptotic cancer cells (2, 5), the increased concentrations of GAPDH mRNA detected may be caused by apoptosis in the placental residue in our case. We conclude that real-time quantitative RT-PCR is a sensitive method to monitor changing mRNA concentrations resulting from apoptotic effects in the placenta and to evaluate invading conditions of the trophoblastic villus.